Altered Functional Connectivity in Patients with Transient Ischemic Attack by Resting-state Functional MRI

GUO Jian, CUI Shu-hui, GUO Yi-jia.et al

Abstract

To investigate longitudinal changes in functional connectivity during resting-state in patients with transient ischemic attack (TIA). Methods35 patients first suffering TIA in the right hemisphere were recruited,with 35 healthy volunteers were recruited as control. At 1 week and 3 months after TIA attack,functional magnetic resonance imaging (fMRI) scans were performed,then resting-state functional connectivity was assessed and compared with that of healthy subjects. Right inferior prefrontal cortex (iPFC) and its mirror region was used as region of interest (ROI) in this analysis. ResultsCompared with controls,higher functional connectivity with the left cerebellum,right superior temporal gyrus (STG) and insula,and lower functional connectivity with the right middle frontal gyrus (MFG) was demonstrated in patients at 1 week after TIA; while decreased functional connectivity in right STG,left insula and bilateral thalamus was shown in patients at 3 month after TIA. Correlation analysis found that functional connectivity of right iPFC with the cerebellum and insula was positively correlated with 2-back reaction time at 1 week after TIA. ConclusionAlthough the nervous system signs of TIA can be quickly recovered,abnormal activation of working memory-related brain regions will occur for a long time.

 

Keywords: Functional magnetic resonance imaging, Functional connectivity, Transient ischaemic attack, Working memory 

 

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References


SACHDEV PS.BRODATY H, VALENZUELA MJ, et al. The neuropsychological profile of vascular cognitive impairment in stroke and TIA patients. Neurology, 2004 , 62 (6):912-919.

PENDLEBURY ST, CUTHBERTSON FC. WELCH SJ, et al. Underestimation of cognitive impairment by Mini-Mental State Examination versus the Montreal Cognitive Assessment in patients with transient ischemic attack and stroke; a population-based study. Stroke,2010,41(6); 1290-1293.

BARKER FC, KLIJN CJ, JENNEKENS-SCHINKEL A, et al. Cognitive impairment in patients with carotid artery occlusion and ipsilateral transient ischemic attacks. J Neurol. 2003,250(11); 1340-1347.

GUOJ, CHEN N, LI R, et al. Regional homogeneity abnormalities in patients with transient ischaemic attack; a resting-state fMRI study. Clin Neurophysiol,2014, 125(3) : 520-525.

LIN ZC, TAO J, GAO YL, et al. Analysis of central mechanism of cognitive training on cognitive impairment after stroke; resting-state functional magnetic resonance imaging study. J Int Med Res,2014,42(3);659-668.

SUN YW,QIN LD, ZHOU Y, et al. Abnormal functional connectivity in patients with vascular cognitive impairment, no dementia; a resting-state functional magnetic resonance imaging study. Behav Brain Res,2011,223(2) :388-394.

GUOJ, WANG S. LI R. et al. Cognitive impairment and whole brain diffusion in patients with carotid artery disease and ipsilateral transient ischemic attack. Neurol Res,2014,36 (1) : 41 -46.

HARVEY PO.FOSSATI P.POCHON JB, et al. Cognitive control and brain resources in major depression: an fMRI study using the n-back task. Neuroimage, 2005 , 26 ( 3): 860- 869.

SCHMAHMANN JD. SHERMAN JC. The cerebellar cognitive affective syndrome. Brain, 1998, 121 ( Pt 4 ); 561- 579.

ZIEMUS B,BAUMANN O, LUERDING R, et al. Impaired working-memory after cerebellar infarcts paralleled by changes in BOLD signal of a cortico-cerebellar circuit. Neuropsychologia, 2007,45( 9):2016-2024.

CAUDA F, DAGATA F, SACCO K, et al. Functional connectivity of the insula in the resting brain. Neuroimage, 2011,55(1); 8-23.

CRAIG AD. How do you feel, Interoception; the sense of the physiological condition of the body. Nat Rev Neurosci,2002, 3(8):655-666.

CARTER AR, ASTAFIEV SV, LANG CE, et al. Resting interhemispheric functional magnetic resonance imaging connectivity predicts performance after stroke. Ann Neurol, 2010,67(3):365-375.

LIN CJ, TU PC, CHERN CM, et al. Connectivity features for identifying cognitive impairment in presymptomatic carotid stenosis. PLoS One, 2014, 9 ( 1 ): e85441 [2018-02- 26]. https;//doi. org/10. 1227/01. neu. 0000445332. 48541. 09.

LIU MG,KANG SJ.SHI TY, et al. Long-term potentiation of synaptic transmission in the adult mouse insular cortex: multielectrode array recordings. J Neurophysiol, 2013, 110 (2):505-521.

FRUHHOLZ S, К LA AS HS, PATEL S, et al. Talking in fury; the cortico-subcortical network underlying angry vocalizations. Cereb Cortex,2015 ,25(9) ;2752-2762.

SELEMON LD, GOLDMAN-RAKIC PS. Common cortical and subcortical targets of the dorsolateral prefrontal and posterior parietal cortices in the rhesus monkey; evidence for a distributed neural network subserving spatially guided behavior. J Neuiosci, 1988,8( 11) ;4049-40G8.

BOR J, BRUNELIN J, SAPPEY-MARINIER D, et al. Thalamus abnormalities during working memory in schizophrenia. An fMRI study. Schizophr Res,2011,125( 1): 49-53.

MEEHAN SK, R A N DH A W A B.WESSEL B, et al. Implicit sequence-specific motor learning after subcortical stroke is associated with increased prefrontal brain activations; an fMRI study. Hum Brain Mapp.2011,32(2) :290-303.

ZHANG Z, LIU Y. JIANG T, et al. Altered spontaneous activity in Alzheimer’s disease and mild cognitive impairment revealed by Regional Homogeneity. Neuroimage, 2012, 59 (2):1429-1440.

MURPHY K.BIRN RM, HANDWERKER DA, et al. The impact of global signal regression on resting state correlations; are anti-correlated networks introduced,Neuroimage,2009,44(3);893-905.

UDDIN LQ, KELLY AM, BISWAL BB, et al. Functional connectivity of default mode network components; correlation, anticorrelation, and causality. Hum Brain Mapp,2009,30(2);625-637.

DE REUCK JL. Evidence for chronic ischaemia in the pathogenesis of vascular dementia; from neuroPATH to neuroPET. Acta Neurol Belg, 1996,96(3);228-231.

MYERSON J, HALE S, RHEE SH, et al. Selective interference with verbal and spatial working memory in young and older adults. J Gerontol В Psychol Sci Soc Sci, 1999,54 (3) :P161-P164.


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