A Retrospective Analysis of Clinical Features of Interstitial Pneumonia with Autoimmune Features

CUI Bei-bei, WU Yang, LIU Huan. et al

Abstract

To analyze the clinical features of interstitial pneumonia with autoimmune features （IPAF） and the correlation between them. MethodsWe respectively analyzed the patients with interstitial lung disease （ILD） admitted in our hospital from January 2014 to January 2017. The patients who met all priori requirements and at least one feature of one domain were recuited,and the clinical features and autoimmune diseases related prognosis were analyzed. ResultsThere were 90 patients recruited, including 38 patients completely met IPAF classification criteria and 52 patients who incompletely met. The average age was (62.34±14.98) yr.. The pneumonia pattern of complete IPAF patients was non-specific interstitial pneumonia (NSIP), while it was usually interstitial pneumonia (UIP) in the incomplete IPAF patients. During follow-up, 11 patients were diagnosed with autoimmune diseases （4 with complete IPAF, and 7 with incomplete IPAF）. According to Cox regression analysis, completely meet the criteria of IPAF was related to the relapse of disease. ConclusionsThere exist relation between IPAF and autoimmune diseases. The patients with IPAFmay finally develop into autoimmune diseases. The IPAF classification criteria provide basic structure for this disease, but the limitation of the criteria call for revising by more clinical trials.

 

Keywords: Interstitial pneumonia with autoimmune features, Autoimmune diseases, Autoimmune antibodies, Classification criteria 

 

Full Text:

PDF


References


FISCHER A, ANTONIOU К. BROWN К, et al. An official European Respiratory Society/American Thoracic Society research statement; interstitial pneumonia with autoimmune features. Eur Respir J ,2015,46(4) ;976-987. CHARTRAND S, SWIGRIS JJ, STANCHEV L, et al.

Clinical features and natural history of interstitial pneumonia with autoimmune features:a single center experience. Respir Med,2016, 119; 150-154 [2017-11-05]. http;//dx. doi. org/ 10. 1016/j. rmed. 2016. 09. 002.

DEMORUELLE MK, MITTOO S, SOLOMON JJ. Connective tissue disease-related interstitial lung disease. Best Pract Res Clin Rheumatol,2016,30( 1) ;39-52.

HAYAHARAC, IKEDA K, SAKANISHI Y, et al. Incidence of serum rheumatoid factors in elder non-rheumatic individuals. Rinsho Byori,2010,58(3) ;211-215.

ARBUCKLE MR, MCCLAIN MT, RUBERTONE MV, et al. Development of autoantibodies before the clinical onset of systemic lupus erythematosus. N Engl J Med, 2003, 349 (16); 1526-1533.

HAMAGUCHI Y. Autoantibody profiles in systemic sclerosis; predictive value for clinical evaluation and prognosis. J Dermatol,2010,37(1):42-53.

KATSUMATA Y, KAWAGUCHI Y, YAMANAKA H. Interstitial lung disease with ANCA-associated vasculitis. Clin Med Insights Circ Respir Pulm Med,2015,9 (Suppl 1): 51-56.

COLLINS B, RAGHU G. Interstitial pneumonia with autoimmune features; the new consensus-based definition for this cohort of patients should be broadened. Eur Respir J, 2016,47(4):1293-1295.

FISCHER A, COLLARD HR, COTTIN V. Interstitial pneumonia with autoimmune features; the new consensus- based definition for this cohort of patients should be broadened. Eur Respir J,2016,47(4) ; 1295-1296.

STREK ME. OLDHAM JM. ADEGUNSOYE A, et al. A call for uniformity in implementing the IPAF ( interstitial pneumonia with autoimmune features) criteria. Eur Respir J. 2016,48(6):1813-1814.

CHARTRAND S. LEE JS, FISCHER A. Longitudinal assessment of interstitial pneumonia with autoimmune features is encouraged. Respir Med.2017 , 132;267[2017-11- 05]. http: //dx. doi. org/10. 1016/j. rmed. 2017. 07. 015.

PLOCINICZAK A, GOZDZIK-SPYCHALSKA J. BATURA-GABRYEL HB. Interstitial pneumonia with autoimmune features ( IPAF ) and radiological findings suggestive of lymphocytic interstitial pneumonia (LIP) case report. Adv Respir Med.2017,85( 1) ;46-50.

NISHIYAMA O, TOHDA Y. Interstitial pneumonia with autoimmune features. Nihon Rinsho Meneki Gakkai Kaishi. 2017.40(3);139-144.


Refbacks

  • There are currently no refbacks.