Diagnosis and Minimally Invasive Endoscopic Treatment of Early Esophageal Cancer and Precancerous Lesions
Abstract
Esophageal cancer is a common malignancy of digestive tract, and its prognosis is closely related to early diagnosis and treatment. In recent years, with the development of endoscopic diagnosis and treatment technology, especially the breakthrough progress of new endoscopic equipments, the detection rate of early esophageal cancer and precancerous lesions is significantly improved, and more and more patients with early esophageal cancer can be treated with minimally invasive endoscopic treatment. At present, endoscopic dissection has become the preferred treatment for early esophageal cancer and precancerous lesions. The advantages is not only less traumatic than traditional surgery, but also retain the physiological structure of esophagus, achieve accurate postoperative pathology and better postoperative quality of life of patients. However, endoscopic minimally invasive treatment in progress also face new problems to be solved, such as how to deal with multifocal esophageal lesions, how to estimate esophageal lesions infiltration depth and lymph node metastasis risk accurately, how to understand the discrepancy between biopsy and postoperative pathology, how to deal with the positive resection margins as well as intraoperative and postoperative complications, how to manage endoscopic treatment of the special subpopulation of the patients, whether and when additional radical surgery should be provided to the patients with non-curative endoscopic treatment, and so on. Aiming to the above problems and the purpose to improve the prognosis and the quality of life of esophageal cancer patients, this topic includes a series studies to explore standardized treatment scheme and management strategy for postoperative complications in the endoscopic treatment of early esophageal cancer and precancerious lesions.
Keywords: Early esophageal cancer, Precancerous lesions, Diagnosis, Endoscopic treatment
Full Text:
PDFReferences
HERSZENYI L. TULASSAY Z. Epidemiology of gastrointestinal and liver tumors. Eur Res' Med Pharmacol Sci,2010,14(4);249-258.
REBECCA LS, KIMBERLY DM. AHMEDIN JDVM. Cancer statistics,2017. Ca Cancer J Clin,2017.67(1); 7-30. CHEN W, ZHENG R. ZENG H, et al. The incidence and mortality of major cancers in China, 2012. Chin J Cancer, 2016.35(8):430-434.
KNUDSEN B. BEMIS D, TICKOO S, et al. Oral cavity and esophageal carcinogenesis modeled in carcinogen-treated mice. Clin Cancer Res,2004 ,10( 1);301-313.
CIOCIRLAN M. LAPALUS MG. HERVIEU V. et al. Endoscopic mucosal resection for squamous premalignant and early malignant lesions of the esophagus. Endoscopy, 2007, 39(1):24-29.
CARVALHO R, AREIA M, BRITO D, et at. Diagnostic accuracy of lugol chromoendoscopy in the oesophagus in patients with head and neck cancer. Revista Espanola De Enfermedades Digestivas.2013,105(2):79-83.
DAWSEYSM, FLEISCHER DE. WANG GQ. et al. Mucosal iodine staining improves endoscopic visualization of squamous dysplasia and squamous cell carcinoma of the esophagus in Linxian, China. Cancer,2015,83(2);220-231.
MORI M. ADACHI Y. MATSUSHIMA T, et al. Lugol staining pattern and histology of esophageal lesions. Am J Gastroenterol,1993,88(5);701-705.
THOSANI N, SINGH H, KAPADIA A, et al. Diagnostic accuracy of EUS in differentiating mucosal versus submucosal invasion of superficial esophageal cancers;a systematic review and meta-analysis. Gastrointest Endosc, 2012, 75 ( 2 ); 242- 253.
INOUE H. Magnification endoscopy in the esophagus and stomach. Digestive Endosc,2001 , 13(1) ;40-41.
MIZUMOTO T, HI YAM A T. OKA S, et al. Diagnosis of superficial esophageal squamous cell carcinoma invasion depth before endoscopic submucosal dissection. Dis Esophagus, 2018,31 (4)[2018-09-17]. https://doi.org/10. 1093/dote/ doy036.
YU T.GENG J, SONG W. et al. Diagnostic accuracy of magnifying endoscopy with narrow band imaging and its diagnostic 4'alue for invasion depth staging in esophageal squamous cell carcinoma; a systematic review and meta-analysis. Biomed Res Int. 2018, 2018; 8591387[2018-09-17]. https://doi. org/10. 1155/2018/8591387.
PECH (), RABENSTEIN T, MANNER H,et al. Confocal laser endomicroscopy for in vivo diagnosis of early squmous cell carcinoma in the esophagus. Clin Gastroenterol Hepatol, 2008,6(1):89-94,
SUN F, YUAN P, CHEN T, et al. Efficacy and complication of endoscopic submucosal dissection for superficial esophageal carcinoma: a systematic review and meta-analysis. J Cardiothorac Surg,2014,9( 1);78.
HIGUCHI K, TANABE S, AZUMA M, et al. A phase Ц study of endoscopic submucosal dissection for superficial esophageal neoplasms. Gastrointest Endosc, 2013, 78 ( 5 ): 704-710.
MUTOM, SATAKE H, YANO T, et al. Long-term outcome of transoral organ-preserving pharyngeal endoscopic resection for superficial pharyngeal cancer. Gastrointest Endosc,2011 ,71(3) :477-484.
HUANG R. CAI H. ZHAO X, et al. Efficacy and safety of endoscopic submucosal tunnel dissection for superficial esophageal squamous cell carcinoma; a propensity score matching analysis. Gastrointest Endosc, 2017, 86 ( 3 ); 575- 576.
ZHANG W. ZHAI Y, CHAI N, et al. Single- and double¬tunnel endoscopic submucosal tunnel dissection for large superficial esophageal squamous cell neoplasms. Endoscopy. 2017, 50(5) ; 505-510.
WU Y, ZHANG H, ZHOU B, et al. Clinical efficacy of endoscopic submucosal dissection in the treatment of early esophageal cancer and precancerous lesions. J Cancer Res Ther, 2018,14(l);52-56.
ONOS, FUJISHIRO M. NIIMI K. et al. Predictors of postoperative stricture after esophageal endoscopic submucosal dissection for superficial squamous cell neoplasms. Endoscopy,2009,41 (8);661-665.
HASHIMOTO S. KOBAYASHI M. TAKEUCHI M. et al. The efficacy of endoscopic triamcinolone injection for the prevention of esophageal stricture after endoscopic submucosal dissection. Gastrointest Endosc» 2011. 74 ( 6 ) : 1389-1393.
Refbacks
- There are currently no refbacks.



