Obesity and Bone Mineral Density in Menopausal Women
Abstract
To determine the association between obesity and bone mineral density in menopausal women. Methods We recruited menopausal women aged 50 years and older who undertook health examinations in West China Hospital of Sichuan University in this study. Bone mineral density of the participants was measured by MetriScan Bone Densitometry. The participants were categorized into three groups according to the T value: normal density, osteopenia and osteoporosis. Results Of the 4 938 participants, 8.55% had obesity 〔body mass index (BMI)>28 kg/m2〕. The three groups of participants were different in BMI, a body shape index (ABSI), body mass, waist circumference, hip circumference and height ( P<0.01). The age-adjusted T values were positively correlated with height, body mass, waist circumference, hip circumference, waist-hip ratio (WHR), waist-height ratio (WHtR) and body roundness index (BRI) ( P<0.05). The areas under curves (AUC) of receiver operator characteristic (ROC) were 0.540 and 0.568, respectively, for waist circumference and BMI in those with osteoporosis. Conclusion Obesity in menopausal women is negatively associated with osteoporosis. The clinical significance of such an association requires further studies with a longitudinal design.
Keywords: Women, Menopause, Osteoporosis, Obesity, Bone mineral density
Full Text:
PDFReferences
FOX CS, MASSARO JM, HOFFMANN U, et al. Abdominal visceral and subcutaneous adipose tissue compartments: association with metabolic risk factors in the Framingham Heart Study. Circulation, 2007,116(1); 39-48.
MENDEZ JP, ROJANO-MEJLA D, PEDRAZA J, et al. Bone mineral density in postmenopausal Mexican-Mestizo women with normal body mass index, overweight,or obesity. Menopause,2013,20(5):568-572.
COOPER C REGINSTER JY, CORTET B, et al. Longterm treatment of osteoporosis in postmenopausal women: a review from the European Society for Clinical and Economic Aspects of Osteoporosis and Osteoarthritis (ESCEO) and the International Osteoporosis Foundation (IOF). Curr Med Res Opin,2012,28(3);475-491.
GEHLBACH S, SAAG KG. ADACHl JD, et al. Previous fractures at multiple sites increase the risk for subsequent fractures; the Global Longitudinal Study of Osteoporosis in Women. J Bone Miner Res,2012,27(3);645-653.
SINAKI M, PFEIFER M, PREISINGER E. et al. The role of exercise in the treatment of osteoporosis. Curr Osteoporos Rep,2010,8(3):138-144.
BECK TJ, PETIT MA, WU G, et al. Does obesity really make the femur stronger? BMD. geometry, and fracture incidence in the women ’ s health initiative-observational study. J Bone Miner Res,2009,24(8): 1369-1379.
KRAKAUER NY, KRAKAUER JC. A new body shape index predicts mortality hazard independently of body mass index. PLoS One,2012,7(7) :е39504[2016-10-13]. http:// dx. doi. org/10. 1371/journal, pone. 0039504.
THOMAS DM, BREDLAU C, BOSY-WESTPHAL A, et al. Relationships between body roundness with body fat and visceral adipose tissue emerging from a new geometrical model. ()besity,2013,21(11): 2264-2271.
GARVEY WT, GARBER AJ, MECHANICK JI, et al. American association of clinical endocrinologists and american college of endocrinology consensus conference on obesity: building an evidence base for comprehensive action. Endocr Pract,2014,20(9):956-976.
GARVEY WT, GARBER AJ, MECHANICK JI, et al. American association of clinical endocrinologists and american college of endocrinology position statement on the 2014 advanced framework for a new diagnosis of obesity as a chronic disease. Endocr Pract,2014 ,20(9) :977-989.
FENG RN, ZHAO C, WANG C, et al. BMI is strongly associated with hypertension, and waist circumference is strongly associated with type 2 diabetes and dyslipidemia. in northern Chinese adults. J Epidemiol,2012,22(4);317-323.
EL HAGER, BACHOUR F, SEBAALY A, et al. The influence of weight status on radial bone mineral density in Lebanese women. Calcif Tissue Int,2014 ,94(4) ;465-467. REID IR. Relationships among body mass, its components, and bone. Bone,2002,31 (5) ,547-555.
CAMACHO PM. PETAK SM. BINKLEY N. et al. American association of clinical endocrinologists and american college of endocrinology clinical practice guidelines for the diagnosis and treatment of postmenopausal osteoporosis 2016. Endocr Pract,2016,22(Suppl 4): 1-42.
EASTELL R, O'NEILL TW. HOFBAUER LC. et al. Postmenopausal osteoporosis. Nat Rev Dis Primers. 2016 (2); 16069Г2016-10-09]. http://www. nature, com/articles/ nrdp201669. doi; 10. 1038/nrdp. 2016. 69.
SAVONITTO S. COLOMBO D, FRANCO N. et al. Age at menopause and extent of coronary artery disease among postmenopausal women with acute coronary syndromes. Am J Med, 2016.129( 11) : 1205-1212.
LOBORA. DAVIS SR. DE VILLIERS TJ. et al. Prevention of diseases after menopause. Climacteric,2014 ,17 (5):540-556.
MERZ AA, CHENG S. Sex differences in cardiovascular ageing. Heart .2016.102(11): 825-831.
AL-HARIRI M. Sweet Bones; The pathogenesis of bone alteration in diabetes. J Diabetes Res. 2016 ( 2016): 6969040 [2016-10-13]. http://dx.doi.org/10. 1155/2016/6969040.
Refbacks
- There are currently no refbacks.
