Lesion Locations and Quality of Life in Patients with Ischemic Stroke

YAN Pei-jing, ZHAN Feng-yu, HOU Li-sha. et al

Abstract

To determine the relationship between lesion locations and quality of life (QOL) in patients with ischemic stroke. Methods The QOL of 456 stroke survivors was assessed two years after the occurrence of stroke. The EQ-5I) was used for measuring QOL. Lesion locations of the patients were identified with CT, MRI and clinical features. Risk factors associated with QOL were identified using a multi-level model. Results Among the 456 stroke survivors, 61. 62% (3/5) had ACT lesions, and more than half of ACI occurred in the subcortex. The number of stroke survivors with left and right hemisphere lesions was almost equal. Different QOL was found between stroke survivors with a right-side brain lesion and those with non-brain lesions (P<0. 001). Significant differences in QOL were also found between those with a subcortex of anterior circulation lesion and others (P<0. 044). Conclusion Lesion locations are associated with QOL. Future studies should pay attention to lesion locations classified by vascular territory and brain anatomical structures and size of lesions.


Keywords: Ischemic stroke Lesion location Quality of life Multi-level model


Full Text:

PDF


References


Lozano R, Naghavi M, Foreman K, et al. Global and regional mortality from 235 causes of death for 20 age groups in 1990 and 2010: a systematic analysis for the Global Burden of Disease Study 2010. Lancet,2012;380(9859) :2095-2128.

Murray CJL, VosT, Lozano R, et al. Disability-adjusted life years (DALYs) for 291 diseases and injuries in 21 regions, 1990-2010: a systematic analysis for the Global Burden of Disease Study 2010. Lancet,2012;380(9859) :2197-2223.

Feigin VL, Forouzanfar MH, Krishnamurthi R, et al. Global and regional burden of stroke during 1990-2010; findings from the Global Burden of Disease Study 2010. Lancet, 2014; 383 (9913);245-255.

Yang G, Wang Y, Zeng Y, et al. Rapid health transition in China, 1990-2010; findings from the Global Burden of Disease Study 2010. Lancet ,2013; 381( 9882): 1987-2015.

Dafer RM, Rao M, Shareef A, et al. Poststroke depression. Top Stroke Rehabil.2008; 15(1); 13-21.

Pugh KG, Lipsitz LA. The microvascular frontal-subcortieal syndrome of aging. Neurobiol Aging,2002?23(3) ;421-431.

Sturm JW. Osborne RH, Dewey HM, et al. Brief comprehensive quality of life assessment after stroke; the assessment of quality of life instrument in the north East melbourne stroke incidence study (NEMESIS). Stroke,2002; 33(12):2888-2891.

Suenkeler IH, Nowak M. Misselwitz B. et al. Timecourse of health-related quality of life as determined 3, 6 and 12 months after stroke. J Neurol,2002 ;249(9) : 1160-1167.

Hopman WM, Verner J. Quality of life during and after inpatient stroke rehabilitation. Stroke,2003;34(3) ;801-805.

Rachpukdee S, Howteerakul N, Suwannapong N, et al. Quality of life of stroke survivors; a 3-month follow-up study. J Stroke Cerebrovasc Dis,2013;22(7) ;e70-e78.

Moon YS, Kim SJ . Kim HC, et al. Correlates of quality of life after stroke. J Neurol Sci,2004;224(1-2);37-41.

Nys GMS, van Zandvoort MJE, van der Worp HB, et al. Early cognitive impairment predicts long-term depressive symptoms and quality of life after stroke. J Neurol Sci,2006; 247(2):149-156.

Ghatnekar О, Eriksson M, Glader EL. Mapping health outcome measures from a stroke registry to EQ-5D weights. Health Qual Life Outcomes,2013; 11 (1);34-40.

Wang H, Kindig Г). Mullahy J. Variation in Chinese population health related quality of life; Results from a EuroQol study in Beijing. China. Qual Life Res. 2005 ; 14 ( 1): 119-132.

Saeki S. Ogata H. Hachisuka K, et al. Association between location of the lesion and discharge status of ADL in first stroke patients. Arch Phys Med Rehabil, 1994 ; 75(8) :858-860.

Beloosesky Y, Streifler J. Burstin A, et al. The importance of brain infarct size and location in predicting outcome after stroke. Age Ageing,1995?24(6);515-518.

Niemi ML. Laaksonen R, Kotila M, et al. Quality of life 4 years after stroke. Stroke,1988; 19(9): 1101-1107.

Gbiri CA, Akinpelu AO. Quality of life of Nigerian stroke survivors during first 12 months post-stroke. Hong Kong J Physiother, 2012 ;30( 1): 18-24.

Haley WE. Roth DL. Kissela B, et al. Quality of life after stroke: a prospective longitudinal study. Qual Life Res. 2011; 20(6):799-806.

de Haan RJ , Limburg M, Van der Meulen JHP. et al. Quality of life after stroke. Impact of stroke type and lesion location. Stroke,1995;26(3):402-408.

Christensen MC, Mayer S. Ferran JM. Quality of life after intracerebral hemorrhage results of the Factor Seven for Acute Hemorrhagic Stroke (FAST) Trial. Stroke,2009;40(5); 1677- 1682.

Caplan L. Posterior circulation ischemia; then, now, and tomorrow. The Thomas Willis Lecture 2000. Stroke, 2000;31(8);2011-2023.

Tao WD, Kong FY, Hao ZL, et al. One-year case fatality and disability after posterior circulation infarction in a Chinese hospital-based stroke study. Cerebrovasc Dis,2010;29(4): 376- 381.

Roman GC, Erkinjuntti T, Wallin A, et al. Subcortical ischaemic vascular dementia. Lancet Neurol. 2002; 1 ( 7): 426- 436.


Refbacks

  • There are currently no refbacks.