Oxidative Stress Level of Vanadium-exposed Workers

WEI Teng-da, LI Shun-pin, LIU Yun-xing. et al

Abstract

To determine the oxidative stress level in peripheral blood of vanadium-exposed workers» as an indication of population health effect of vanadium on human neurobehavioral system. Methods 86 vanadium-exposed workers and 65 non-exposed workers were recruited by cluster sampling. A questionnaire was administered to collect demographic and occupational exposure information. Serum activity of superoxide dismutase (SOI))» inducible nitric oxide synthase (iNOS ) and malonaldehyde (MDA) contents were detected by kit assay. The differences in oxidative stress level between vanadium-exposed and non-exposed workers were compared. Results Vanadium-exposed workers had higher levels of MDA contents than the controls. The total superoxide dismutaseCT-SOD)activity in vanadium-exposed workers was significantly lower than that in the controls, which was associated with lowered levels of manganese superoxide dismutase (Mn-SOD) activity. No changes in serum levels of cupro-zinc superoxide dismutase (CuZn-SOD) was found in vanadium-exposed workers. No difference in iNOS activity was found between vanadium-exposed workers and controls. Conclusion Vanadium exposure increases free radical production in serum and reduces antioxidant capacity. But the relationship between vanadium exposure and iNOS damage remains uncertain.


Keywords: Vanadium compound, Oxidative stress

 

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Olopade JO. Fatola Ю, Olopade FE. Vertical administration of vanadium through lactation induces behavioural and neuromorphological changes: protective role of vitamin E. Niger J Physiol Sci.2011 ;26( 1):55-60.

Avila-Costa K. Fortoul 1. Nino-Cabrera G. et al. Hippocampal cell alterations induced by the inhalation of vanadium pentoxide (V2O5)promote memory deterioration. Neurotoxicology«2006; 27(6): 1007-1012.

Beatriz GG« Eugenia BM. Dario QA . Vanadium (V) - induced neurotoxicity in the rat central nervous system: a histo- immunohistochemical study. Drug Chem Toxicol.2005;28(3): 329-344.

Sandra C* Christoffer T. Qing Z. et al. Mechanisms and modulation of neural cell damage induced by oxidative stress. Physiol Behav.2007 ;92( 1-2): 87-92.

Evangelou AM. Vanadium in cancer treatment. Crit Rev Oncol HematoL2002;42(3):249-265.

Chen F. Demers LM. Vallyathan V, et al. Vanadate induction of NF-kappaB involves IkappaB kinase beta and SAPK /ERK kinase 1 in macrophages. J Biol Chem» 1999; 274 (29): 20307- 20312.

Garcia GB. Quiroga AD, Sturtz N, et al. Morphological alterations of central nervous system ( CNS) myelin in vanadium (V)-exposed adult rats. Drug Chem Toxicol.2004;2 (3):281-293.

Haider SS. Abdel-Gayoum АА, El-Fakhri M. Effect of seleium on vanadium toxicity in different regions of rat brain. H um Exp Toxicol Л998; 17( 1): 23-28.

Sasi MM, Haider SS. el-Fakhri M. et al. Microchromatographic analysis of lipids, protein* and occurrence of lipid peroxidation in various brain areas of vanadium exposedrats: a possible mechanism of vanadium neurotoxicity. Neurotoxicology. 1994 :15(2) :413-420.

Cuesta S. Proietto R. Garcia GB. Astrogliosis and HSP70 activation in neonate rats’ brain exposed to sodium metavanadate through lactation. Neurotoxicol Teratol. 2013; 37:57-62.

Fischer Gunther TM, Kviecinski Roberto M, Cristine Baron С, et al. Sodium orthovanadate associated with pharmacological doses of ascorbate causes an increased generation ROS in tumor cells that inhibits proliferation and triggers apoptosis. Biochem Biophys Res Commun. 2013; 430 (3):883-888.

Cuesta S. Frances D. Garcia GB. ROS formation and antioxidant status in brain areas of rats exposed to sodium metavanadate. Neurotoxicol Teratol.2011 ;33(2):297-302.

Aschner M. Levin D.Suno C. Gene-environment interactions: neuroderation in non-mammals and mammals. Neurotoxicology .2010; 31 (5): 582-588.

Bergendi L. Benes L. Durackova Z. et al. Chemistry, physiology and pathology of free radicals . Life Sci.l999;65 (18-19): 1865-1874.


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