Vitamins and Immune System Health

KONG Wei-li, LU Xin-rong, HOU Lin-lin, SUN Xiu-fa, SUN Gui-qin, CHEN Li

Abstract

Keeping the immune system healthy forms an effective way to fight infections. Past experience has shown that, in addition to effective interventions including vaccination, drug therapy, and non-pharmaceutical intervention (NPI), dietary nutrition and mental health are also key factors in maintaining immune system health and combating emerging and sudden outbreaks of infections. As the main dietary nutrients, vitamins are active regulators of the immune response and exert a critical impact on the immunity of the human body. Vitamin deficiency causes increased levels of inflammation and decreased immunity, which usually starts in the oral tissues. Appropriate vitamin supplementation can help the body optimize immune function, enhance oral immunity, and reduce the negative impact of pathogen infection on the human body, which makes it a feasible, effective, and universally applicable anti-infection solution. This review focuses on the immunomodulatory effects of vitamin A, B, C, D, and E and proposes that an omics-based new systemic approach will lead to a breakthrough of the limitations in traditional single-factor single-pathway research and provide the direction for the basic and applied research of vitamin immune regulation and anti-infection in all aspects.

 

Keywords: Vitamin, Immunity, Infections


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References


SADIGHI A A. Aging and the immune system: an overview. J Immunol Methods，2018，463: 21–26. doi: 10.1016/j.jim.2018.08.005.

MAGGINI S， PIERRE A， CALDER P C. Immune function and micronutrient requirements change over the life course. Nutrients，2018， 10(10): 1531. doi: 10.3390/nu10101531.

CARR A C， MAGGINI S. Vitamin C and immune function. Nutrients， 2017，9(11): 1211. doi: 10.3390/nu9111211.

WOLBACH S B， HOWE P R. Tissue changes following deprivation of fat-soluble a vitamin. J Exp Med，1925，42(6): 753–777. doi: 10.1084/jem. 42.6.753.

GREEN H N， MELLANBY E. Vitamin A as an anti-infective agent. Br Med J，1928，2(3537): 691–696. doi: 10.1136/bmj.2.3537.691.

TIMONEDA J， RODRÍGUEZ-FERNÁNDEZ L， ZARAGOZÁ R， et al. Vitamin A Deficiency and the lung. Nutrients，2018，10(9): 1132. doi: 10. 3390/nu10091132.

CANTORNA M T， SNYDER L， ARORA J. Vitamin A and vitamin D regulate the microbial complexity, barrier function, and the mucosal immune responses to ensure intestinal homeostasis. Crit Rev Biochem Mol Biol，2019，54(2): 184–192. doi: 10.1080/10409238.2019.1611734.

GUTIERREZ G A， MARTINEZ-MIER E A. Chapter 6: vitamins and oral health. Monogr Oral Sci，2020，28: 59–67. doi: 10.1159/000455372.

SZYMANSKI L， SKOPEK R， PALUSINSKA M， et al. Retinoic acid and its derivatives in skin. Cells，2020，9(12): 2660. doi: 10.3390/cells9122660.

CHENG R Z. Can early and high intravenous dose of vitamin C prevent and treat coronavirus disease 2019 (COVID-19)? Med Drug Discov， 2020，5: 100028. doi: 10.1016/j.medidd.2020.100028.

TIAN Y， NICHOLS R G， CAI J， et al. Vitamin A deficiency in mice alters host and gut microbial metabolism leading to altered energy homeostasis. J Nutr Biochem，2018，54: 28–34. doi: 10.1016/j.jnutbio. 2017.10.011.

Van De PAVERT S A， FERREIRA M， DOMINGUES R G， et al. Maternal retinoids control type 3 innate lymphoid cells and set the offspring immunity. Nature，2014，508(7494): 123–127. doi: 10.1038/ nature13158.

ZHOU W， ZHOU L， ZHOU J， et al. ZBTB46 defines and regulates ILC3s that protect the intestine. Nature，2022，609(7925): 159–165. doi: 10.1038/s41586-022-04934-4.

BLAKELEY M， SOBCZYNSKA-MALEFORA A， CARPENTER G. The origins of salivary vitamin A, vitamin B(12) and vitamin D-binding proteins. Nutrients，2020，12(12): 3838. doi: 10.3390/nu12123838.

LEHMANN-CHE J， BALLY C， LETOUZE E， et al. Dual origin of relapses in retinoic-acid resistant acute promyelocytic leukemia. Nat Commun，2018，9(1): 2047. doi: 10.1038/s41467-018-04384-5.

KINOSHITA M， PASATIEMPO A M， TAYLOR C E， et al. Immunological memory to tetanus toxoid is established and maintained in the vitamin A-depleted rat. FASEB J，1991，5(10): 2473–2481. doi: 10. 1096/fasebj.5.10.2065894.

TURRUBIATES-HERNANDEZ F J， HERNANDEZ-BELLO J， OREGON-ROMERO E， et al. The involvement of vitamin A in the production of secretory IgA in the respiratory epithelium for potential protection against SARS-CoV-2 infection. Rev Alerg Mex，2021，68(3): 185–197. doi: 10.29262/ram.v68i3.977.

TANG D， LIU S， SUN H， et al. All-trans-retinoic acid shifts Th1 towards Th2 cell differentiation by targeting NFAT1 signalling to ameliorate immune-mediated aplastic anaemia. Br J Haematol，2020， 191(5): 906–919. doi: 10.1111/bjh.16871.

SCHOLZ J， KUHRAU J， HEINRICH F， et al. Vitamin A controls the allergic response through T follicular helper cell as well as plasmablast differentiation. Allergy，2021，76(4): 1109–1122. doi: 10.1111/all.14581.

ZHANG Y， LU Y， WANG S， et al. Excessive vitamin A supplementation increased the incidence of acute respiratory tract infections: a systematic review and meta-analysis. Nutrients，2021，13(12): 4251. doi: 10.3390/nu13124251.

SPINAS E， SAGGINI A， KRITAS S K， et al. Crosstalk between vitamin b and immunity. J Biol Regul Homeost Agents，2015，29(2): 283–288. DOMINGUEZ-ANDRES J， JOOSTEN L A， NETEA M G. Induction of innate immune memory: the role of cellular metabolism. Curr Opin Immunol，2019，56: 10–16. doi: 10.1016/j.coi.2018.09.001.

BUCK M D， SOWELL R T， KAECH S M， et al. Metabolic instruction of immunity. Cell，2017，169(4): 570–586. doi: 10.1016/j.cell.2017.04.004. SMITH T J， JOHNSON C R， KOSHY R， et al. Thiamine deficiency disorders: a clinical perspective. Ann N Y Acad Sci，2021，1498(1): 9–28. doi: 10.1111/nyas.14536.

PETERSON C T， RODIONOV D A， OSTERMAN A L， et al. B vitamins and their role in immune regulation and cancer. Nutrients，2020，12(11): 3380. doi: 10.3390/nu12113380.

SUWANNASOM N， KAO I， PRUSS A， et al. Riboflavin: the health benefits of a forgotten natural vitamin. Int J Mol Sci，2020，21(3): 950. doi: 10.3390/ijms21030950.

GRAFF E C， FANG H， WANDERS D， et al. The absence of adiponectin alters niacin's effects on adipose tissue inflammation in mice. Nutrients， 2020，12(8): 2427. doi: 10.3390/nu12082427.


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