Oral Microbiome and Systemic Diseases

ZHOU Lu-jun, CHEN Bo-yan, LI Yu-lin, DUAN Sheng-zhong

Abstract

 As one of the most diverse microbial communities within the human body, the oral microbiome is an important component that contributes to the maintenance of human health. The microbial composition of different sites in the oral cavity varies significantly and a dynamic equilibrium is maintained through communications with the environment and oral and distal organs of the host. It has been reported that there is significant correlation between dysbiotic oral microbiome and the occurrence or progression of a variety of systemic diseases. In this review, we summarized recent advances in research on the relationship between oral microbiome and systemic health, focusing on the interaction and pathological mechanisms between oral microbiome and systemic health and hoping to provide new avenues for the early prevention and clinical diagnosis and treatment of systemic diseases.

 

Keywords: Oral microbiome, Dysbiosis, Systemic diseases

 

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References


Human Microbiome Project C. Structure, function and diversity of the healthy human microbiome. Nature，2012，486(7402): 207–214. doi: 10.1038/nature11234.

ZHAO D， LIU J， WANG M， et al. Epidemiology of cardiovascular disease in China: current features and implications. Nat Rev Cardiol， 2019，16(4): 203–212. doi: 10.1038/s41569-018-0119-4.

KIM J， AMAR S. Periodontal disease and systemic conditions: a bidirectional relationship. Odontology，2006，94(1): 10–21. doi: 10.1007/s10266-006-0060-6.

JONSSON D， ORHO-MELANDER M， DEMMER R T， et al. Periodontal disease is associated with carotid plaque area: the Malmo Offspring Dental Study (MODS). J Intern Med，2020，287(3): 301–309. doi: 10.1111/joim.12998.

XU T， DONG Q， LUO Y， et al. Porphyromonas gingivalis infection promotes mitochondrial dysfunction through Drp1-dependent mitochondrial fission in endothelial cells. Int J Oral Sci，2021，13(1): 28. doi: 10.1038/s41368-021-00134-4.

RHO J H， KIM H J， JOO J Y， et al. Periodontal pathogens promote foam cell formation by blocking lipid efflux. J Dent Res，2021，100(12): 1367–1377. doi: 10.1177/00220345211008811.

NEPOMUCENO R， PIGOSSI S C， FINOTI L S， et al. Serum lipid levels in patients with periodontal disease: a meta-analysis and meta-regression. J Clin Periodontol，2017，44(12): 1192–1207. doi: 10.1111/jcpe.12792.

ZHANG B， SIRSJO A， KHALAF H， et al. Transcriptional profiling of human smooth muscle cells infected with gingipain and fimbriae mutants of Porphyromonas gingivalis. Sci Rep，2016，6: 21911. doi: 10.1038/srep21911.

GOMES-FILHO I S， COELHO J M F， MIRANDA S S， et al. Severe and moderate periodontitis are associated with acute myocardial infarction. J Periodontol，2020，91(11): 1444–1452. doi: 10.1002/JPER.19-0703.

KWUN J S， KANG S H， LEE H J， et al. Comparison of thrombus, gut, and oral microbiomes in Korean patients with ST-elevation myocardial infarction: a case-control study. Exp Mol Med，2020，52(12): 2069–2079. doi: 10.1038/s12276-020-00543-1.

DELEON-PENNELL K Y， IYER R P， ERO O K. Periodontal-induced chronic inflammation triggers macrophage secretion of Ccl12 to inhibit fibroblast-mediated cardiac wound healing. JCI Insight，2017，2(18): e94207. doi: 10.1172/jci.insight.94207.

YOU Z， CUSHMAN M， JENNY N S， et al. Tooth loss, systemic inflammation, and prevalent stroke among participants in the reasons for geographic and racial difference in stroke (REGARDS) study. Atherosclerosis，2009，203(2): 615–619. doi: 10.1016/j.atherosclerosis. 2008.07.037.

SHIMAZAKI Y， SAITO T， KIYOHARA Y， et al. Relationship between electrocardiographic abnormalities and periodontal disease: the Hisayama Study. J Periodontol，2004，75(6): 791–797. doi: 10.1902/jop.2004.75.6.791.

LEE H J， CHOI E K， PARK J B， et al. Tooth loss predicts myocardial infarction, heart failure, stroke, and death. J Dent Res，2019，98(2): 164–170. doi: 10.1177/0022034518814829.

CZERNIUK M R， BARTOSZEWICZ Z， FILIPIAK K J， et al. Plasmatic NT-proBNP concentrations in patients with coexistent periodontal disease and congestive heart failure: pilot studies. Kardiol Pol，2017， 75(2): 135–142. doi: 10.5603/KP.a2016.0148.

SUZUKI J I， SATO H， KANEKO M， et al. Periodontitis and myocardial hypertrophy. Hypertens Res，2017，40(4): 324–328. doi: 10.1038/hr.2016. 146.

TSIOUFIS C， KASIAKOGIAS A， THOMOPOULOS C， et al. Periodontitis and blood pressure: the concept of dental hypertension. Atherosclerosis，2011，219(1): 1–9. doi: 10.1016/j.atherosclerosis.2011.04. 030.


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