Tacrolimus Induces Pain by Upregulating the Synaptic Expression of AMPA Receptors in the Spinal Cord Dorsal Horn
Abstract
Keywords: Tacrolimus, Spinal cord dorsal horn, AMPA receptor, GluA1 subunit, Phosphorylation, Pain
Full Text:
PDFReferences
POSHEKHONTSEVA V Y, FOKINA V V, TARLACHKOV S V, et al. Streptomyces tsukubensis VKM Aс-2618D-an effective producer of tacrolimus. Appl Biochem Microbiol,2021,57(9): 939–948. doi: 10.1134/S0003683821090064.
WHITEHOUSE G, GRAY E, MASTORIDIS S, et al. IL-2 therapy restores regulatory T-cell dysfunction induced by calcineurin inhibitors. Proc Natl Acad Sci U S A,2017,114(27): 7083–7088. doi: 10.1073/pnas. 1620835114.
ILONZE O J, GIOVANNINI M, JONES M A, et al. Calcineurin-inhibitor induced pain syndrome in a heart transplant patient. Transplant Proc,2021,53(8): 2630–2635. doi: 10.1016/j.transproceed.2021.08.014.
CHADHA Y, BRAHME S K, HUANG B K, et al. Calcineurin-inhibitor induced pain syndrome - Magnetic resonance imaging and scintigraphic findings illustrated through two cases. Clin Imaging,2019,53: 174–178. doi: 10.1016/j.clinimag.2018.10.022.
ULLAH A, ALY A, ALI T, et al. Calcineurin inhibitor-induced pain syndrome: an uncommon but a debilitating complication of calcineurin inhibitors use. Saudi J Kidney Dis Transpl,2021,32(6): 1795–1799. doi: 10.4103/1319-2442.352443.
GE Y, WANG Y T. GluA1-homomeric AMPA receptor in synaptic plasticity and neurological diseases. Neuropharmacology,2021,197: 108708. doi: 10.1016/j.neuropharm.2021.108708.
KOPACH O, VOITENKO N. Spinal AMPA receptors: amenable players in central sensitization for chronic pain therapy? Channels (Austin), 2021,15(1): 284–297. doi: 10.1080/19336950.2021.1885836.
ROYO M, ESCOLANO B A, MADRIGAL M P, et al. AMPA receptor function in hypothalamic synapses. Front Synaptic Neurosci,2022,14: 833449. doi: 10.3389/fnsyn.2022.833449.
GUO C, MA Y Y. Calcium permeable-AMPA receptors and excitotoxicity in neurological disorders. Front Neural Circuits,2021,15: 711564. doi: 10.3389/fncir.2021.711564.
KOPACH O, DOBROPOLSKA Y, BELAN P, et al. Ca2+-permeable AMPA receptors contribute to changed dorsal horn neuronal firing and inflammatory pain. Int J Mol Sci,2023,24(3): 2341. doi: 10.3390/ijms24032341.
HUANG Y, CHEN S R, PAN H L. Calcineurin regulates synaptic plasticity and nociceptive transmission at the spinal cord level. Neuroscientist,2022,28(6): 628–638. doi: 10.1177/10738584211046888.
GAN Q, SALUSSOLIA C L, WOLLMUTH L P. Assembly of AMPA receptors: mechanisms and regulation. J Physiol,2015,593(1): 39–48. doi: 10.1113/jphysiol.2014.273755.
CHAPLAN S R, BACH F W, POGREL J W, et al. Quantitative assessment of tactile allodynia in the rat paw. J Neurosci Methods,1994, 53(1): 55–63. doi: 10.1016/0165-0270(94)90144-9.
LI Y, BAI X, GAO M, et al. AKAP150 and its palmitoylation contributed to pain hypersensitivity via facilitating synaptic incorporation of GluA1-containing AMPA receptor in spinal dorsal horn. Mol Neurobiol,2021,58(12): 6505–6519. doi: 10.1007/s12035-021-02570-z.
HUANG Y, CHEN S R, CHEN H, et al. Calcineurin inhibition causes α2δ-1-mediated tonic activation of synaptic NMDA receptors and pain hypersensitivity. J Neurosci,2020,40(9): 3707–3719. doi: 10.1523/JNEUROSCI.0282-20.2020.
WANG Y, WU J, WU Z, et al. Regulation of AMPA receptors in spinal nociception. Mol Pain,2010,6: 5. doi: 10.1186/1744-8069-6-5.
DIERING G H, HEO S, HUSSAIN N K , et al. Extensive phosphorylation of AMPA receptors in neurons. Proc Natl Acad Sci U S A,2016,113(33): E4920–E4927. doi: 10.1073/pnas.1610631113.
ZHAO L X, GE Y H, LI J B, et al. M1 muscarinic receptors regulate the phosphorylation of AMPA receptor subunit GluA1 via a signaling pathway linking cAMP-PKA and PI3K-Akt. FASEB J,2019,33(5): 6622–6631. doi: 10.1096/fj.201802351R.
HELL J W. How Ca2+-permeable AMPA receptors, the kinase PKA, and the phosphatase PP2B are intertwined in synaptic LTP and LTD. Sci Signal,2016,9(425): e2. doi: 10.1126/scisignal.aaf7067.
BAI X, GAO M, LI Y, et al. Upregulation of RCAN1.4 in spinal dorsal horn is involved in inflammatory pain hypersensitivity. Neurosci Lett, 2022,775: 136538. doi: 10.1016/j.neulet.2022.136538.
HU Y M, CHEN S R, CHEN H, et al. Casein kinase Ⅱ inhibition reverses pain hypersensitivity and potentiated spinal N-methyl-D-aspartate receptor activity caused by calcineurin inhibitor. J Pharmacol Exp Ther,2014,349(2): 239–247. doi: 10.1124/jpet.113.212563.
Refbacks
- There are currently no refbacks.